An EU-funded initiative, this project will provide surgeons with a fast, real-time tool for accurate tumor margin assessment, using innovative optical techniques and AI to enhance surgical precision and improve patient outcomes.

 

Spectra-BREAST aims to enhance breast-conserving surgery by developing a cutting-edge intraoperative tool for real-time, accurate assessment of tumor resection margins.

The project brings together a strong consortium of 6 partners, including 1 research hospital, 3 academic research centers, and 2 innovative companies.

Running from 2025 to 2028, Spectra-BREAST is funded with approximately €3 million by the European Innovation Council under the Pathfinder Open 2024 framework (Call HORIZON-EIC-2024-PATHFINDEROPEN-01-01).

Clinical overview

The Challenge in Breast Cancer Surgery

Breast-conserving surgery aims to remove cancerous tissue while preserving healthy breast tissue. However, incomplete tumor removal occurs in about 20% of cases, leading to additional surgeries, increased healthcare costs, and emotional and physical stress for patients. Current margin assessment methods are slow, subjective, and not always accurate. There is a critical need for a fast, reliable, and objective solution to guide surgeons during operations and ensure complete tumor removal.

Innovation

Smart Technologies

SpectraBREAST introduces an innovative, multimodal technology that combines Hyperspectral Imaging (HSI), fiber-optic Raman Spectroscopy (RS), and advanced AI algorithms. This integrated system will provide real-time, high-accuracy feedback on tumor margins within a few minutes, helping surgeons identify and remove residual cancerous tissue during the initial surgery. This solution aims to significantly reduce reoperations, improve patient outcomes, and lower healthcare costs

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Interview: Carlo Morasso Discusses Spectra-BREAST Project

In a recent interview with DEEPSYNC, the heart of European scientific innovation within the EIC Communities project, Carlo Morasso, the coordinator of the Spectra-BREAST project, shared his insights on the impact and challenges of the initiative, which aims to transform breast cancer surgery. Morasso, Head of Laboratory at Istituti Clinici Scientifici Maugeri (ICS Maugeri), emphasized the critical need the project

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New Study: Surgeon Seniority in Breast-Conserving Surgery – Key Insights from Spectra-BREAST

We are pleased to announce the publication of the second part of our study, exploring the impact of localization techniques on positive margin status in breast-conserving surgery (BCS) for non-palpable lesions. This study, part of the Spectra-BREAST project, has provided valuable insights into how surgeon seniority affects surgical outcomes. Key Findings: A standout conclusion from the research is that surgeon

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SpectraBREAST at VISPEC 2026: Advancing Raman and Spectral Imaging for Tumor Margin Assessment

SpectraBREAST was prominently represented at the VISPEC 2026 Conference, held in Pavia, Italy, where members of the consortium actively contributed to the scientific program and outreach activities. Carlo Morasso (ICS Maugeri, project coordinator) and Renzo Vanna (CNR, WP6 leader) co-chaired and organized a dedicated workshop supported by SpectraBREAST, focusing on advanced techniques in Raman spectroscopy and spectral data analysis for

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New Publication: Expert Consensus on Breast Surgery

The Istituti Clinici Scientifici Maugeri (ICSM), coordinator of the Spectra-BREAST project, has published a peer-reviewed article in the international journal BJS Open, presenting an expert consensus on current clinical practice and innovation needs in the field of breast-conserving surgery. Article title:Comparative effectiveness of preoperative localization techniques for non-palpable breast lesions: multicentre real-world studyBJS Open, Volume 10, February 2026DOI: 10.1093/bjsopen/zraf153 This

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Spectra-BREAST Consortium Meeting Held in Rotterdam

On December 3rd and 4th, 2025, the Spectra-BREAST consortium gathered in Rotterdam for a productive two-daymeeting hosted by RiverD International BV. The event saw 13 participants joining in person, with additional partners attending remotely. During the month-12 meeting, the consortium reflected on the progress made in the first 12 months of the project, reviewing the milestones achieved and the challenges

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New Paper on Open Science and FAIR Data in Raman Spectroscopy: Implications for the SpectraBREAST Project

We are pleased to announce the publication of a new paper (link) – published in “ACS Nano” reviewing the principles of Open Science and the FAIR data (Findable, Accessible, Interoperable, and Reusable) framework, with a specific focus on their application in Raman spectroscopy. This paper outlines the evolving landscape of digital tools and open resources, emphasizing how combining Raman spectroscopy

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